In an inducible Myc-mediated model of HCC, mice expressing the tetracyclin-responsive transactivator (tTA) under the control of the liver-enriched transcriptional activator protein (LAP) promotor are crossed with mice bearing Myc under the control of a tTA-regulated promotor (named here LAP-tTA/Myc mice). The gene discussed is MYC; the disease is hepatocellular carcinoma.