DGAT2 and fatty liver disease: Deacylglycerol acyltransferase 2 (DGAT2) catalyzes the de novo synthesis of triglycerols from newly synthesized FAs (CoA + triacylglycerol from acyl-CoA + 1,2-diacylglycerol), while hepatic overexpression of DGAT2 in mice leads to hepatic steatosis [32,33,34].