TP53BP2 and hepatocellular carcinoma: Tumor suppressor P53-binding protein 2 (TP53BP2, also known as apoptosis-stimulating p53 protein 2, ASPP2), a p53 activator, negatively regulates the mevalonate pathway and inhibits the growth of HCC cells, indicating that activation of the mevalonate pathway can play an important role in liver cancer development.