DGK isozymes have been reported to be involved in many physiological events, including cell proliferation and migration, glucose intake, immunity and neuronal network construction, and pathogenesis of a wide variety of diseases, exemplified by cancer, epilepsy, obsessive-compulsive disorder (OCD), bipolar disorder (BPD), fragile X syndrome (FXS), immunodeficiency, cardiac hypertrophy, hypertension, and type 2 diabetes (T2D) [1,2,3,4,5,44,45,46,47,48]. Here, DGKE is linked to type 2 diabetes mellitus.