Although GRP78 protein levels did not change in MCF7(2) or MDA-MB-231 cells (Figures S1A,B, S7 and S8) following BOLD-100 treatment combination of BOLD-100 and olaparib significantly reduced MDA-MB-231 tumor volume and induced increase in gamma-H2AX compared to control. The gene discussed is HSPA5; the disease is neoplasm.