ACE2 and COVID-19: Fundamentally, after entering into the cells via ACE2 receptors and excessive binding of the SARS-CoV-2 result in the downregulation of ACE2 by intracellular degradation and shedding, which could reduce the Ang-II degradation and activation of AT1R with induction of myocardial hyper-inflammatory reaction in response to COVID-19 [49,73].