Nevertheless, earlier clinical studies conveyed that treatment with soluble form of recombinant human ACE2 (rhACE2; APN01 (0.4 mg/kg, IV, BID for 7 days), GSK2586881: 0.4 mg/kg, IV, BID for 3 days) neutralized the excessive SARS-CoV virus in the system and preserved the protective cellular effects of ACE2 in ARDS patients [56,57]. Here, ACE2 is linked to acute respiratory distress syndrome.