CD274 and small cell lung carcinoma: Even lacking clear evidence of adding PD-1/PD-L1 agents to chemotherapy in ECOG PS 2-3 ES SCLC patients, this clinical behavior could anyway provide clinical benefit, as clinical improvements are usually rapidly observed after cytotoxic treatment onset, and immunotherapy (besides increasing the response rates, as seen), could therefore exert its effect on the medium-long term.