CD274 and small cell lung carcinoma: The addition of a PD-1/PD-L1 ICI to platinum-etoposide chemotherapy in patients with ES SCLC was associated with a statistically significant benefit in OS in the whole study ITT population (n = 1553), [hazard ratio (HR) 0.76, 95% confidence interval (CI) 0.68–0.85, p < 0.00001) (Figure 1).