CD274 and small cell lung carcinoma: To the detriment of initial enthusiasms [15], the first clinical proofs of PD-1/PD-L1 immune checkpoint inhibitors (ICIs, combined or not with CTLA-4 ICIs) have been disappointing in the pretreated setting of SCLC and as switch-maintenance strategies, frustrating, in addition, the role of PD-L1 as a biomarker [16,17,18,19].