In the case of Alzheimer’s Disease (AD), which is one of the representative neurodegenerative disease, a few molecules (such as amyloid-beta accumulation and pathological tau formation) have been revealed as responsible for destroying the CNS and inducing AD progression; however, a large part of the solution still remains unclear in the search for a drug target to treat the irreversible destruction from AD [4]. The gene discussed is MAPT; the disease is Alzheimer disease.