The analysis revealed a significantly higher expression of 41 lncRNAs in recurrent and/or metastatic HNSCC patients compared to healthy volunteers with a fold change of 3.2–2.7 × 103 for 21A, Air, Alpha 280, ANRIL, BACE1AS, Dios3os, E2F4 antisense, Emx2os, GAS5, H19, HAR1B, HOXA6as, HULC, Jpx, Kcnq1ot1, KRASP1, lincRNA-RoR, LUST, MALAT1, mascRNA, MEG9, MER11C, ncR-uPAR, NEAT1, NRON, p53 mRNA, PSF inhibiting RNA, PTENP1, RNCR3, SCA8, SNHG1, SNHG3, SNHG4, SNHG6, SRA, ST7OT, TncRNA, Tsix, UCA1, YRNA1 and Zfas1. The gene discussed is MALAT1; the disease is head and neck squamous cell carcinoma.