According to The Cancer Genome Atlas (TCGA) the main genetic alterations present in HNSCC are associated with protein-coding genes involved in cell cycle (CDKN2A, TP53, CCND1), growth signaling (EGFR), survival (PIK3CA, PTEN), WNT signaling (FAT1, AJUBA, NOTCH1) and epigenetic regulation (KMT2D, NSD1). The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.