These modifications determine various histological patterns, ranging from simple steatosis to Non-Alcoholic Steatohepatitis (NASH), defined by necrotic inflammation and fibrogenesis caused by an increase in the production of ROS, which cause lipid peroxidation (oxidative degradation of lipids) and consequent production of pro-inflammatory cytokines (TNF-α, TGF-β, IL-8); the latter collect neutrophils, causing necrosis and collagen synthesis [60]. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.