A triple-masked, randomized, placebo-controlled trial conducted by Kelishadi and colleagues [117] found a significant decrease in Apo B/ApoA-I ratio, ox-LDL, leptin and malondialdehyde, total and LDL-cholesterol and hs-CRP in children with obesity, after they had received zinc sulfate supplementation. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.