Serum zonulin levels were significantly higher in the OB-CRC group compared to L-HC (26.57 ± 14.95 vs. 14.72 ± 9.57, p < 0.001) and L-CRC groups (26.57 ± 14.95 vs. 20.07 ± 15.23, p = 0.013). Here, HP is linked to colorectal carcinoma.