Moreover, we found an obesity-related microbial profile linked to CRC, that could be responsible for the significantly higher serum levels of zonulin (marker of intestinal permeability), TMAO (CVD-related microbial metabolite), and IL-1β (proinflammatory factor) and the lower levels of IL-10 (anti-inflammatory factor) compared to non-obese CRC patients and controls. This evidence concerns the gene HP and obesity due to melanocortin 4 receptor deficiency.