In the present study, we measured the concentration of profibrotic molecules (GM-CSF, ET-1), Th-1 (IFN-gamma, IL-1β, TNF-α, IL-2, IL-6, IL-9), Th-17 (IL-17, IL-21, IL-22, IL-23), and T-reg (IL-10, TGF-β) related cytokines in gastric juice of patients affected with SSc, at the aim to investigate the correlation between their levels and esophageal dysfunction. The gene discussed is IL21; the disease is systemic sclerosis.