More recently, several authors also reported decreased frequency and impaired function of circulating CD4+, CD25+, FoxP3+ human regulatory T cells (Tregs) in SSc patients compared to healthy controls and other autoimmune diseases [9,10,11], thus postulating a Treg/Th17 imbalance as the main component of SSc pathogenesis [12]. This evidence concerns the gene FOXP3 and systemic sclerosis.