In the present study, we measured the concentration of profibrotic molecules (GM-CSF, ET-1), Th-1 (IFN-gamma, IL-1β, TNF-α, IL-2, IL-6, IL-9), Th-17 (IL-17, IL-21, IL-22, IL-23), and T-reg (IL-10, TGF-β) related cytokines in gastric juice of patients affected with SSc, at the aim to investigate the correlation between their levels and esophageal dysfunction. This evidence concerns the gene CSF2 and systemic sclerosis.