TP53 and neoplasm: It has been shown that one-third of KC mice develop PDAC by 500 days [47], and the additional Trp53 mutation in KPC (Pdx1-Cre/KrasG12D/+/Trp53R172H/+) mice or Trp53 deletion in KPflC (Pdx1-Cre/KrasG12D/+/Trp53-/+) mice accelerates the tumor development by 120–180 days [48].