The AHR pathway has also been linked, indirectly, to the pathogenesis of primary open-angle glaucoma (POAG) through its target gene CYP1A1. Glaucoma is a genetically heterogenous optic neuropathy, characterized by the loss of retinal ganglion cells, leading to optic nerve damage and subsequent vision loss [118]. Here, CYP1A1 is linked to open-angle glaucoma.