MAPK8 and breast cancer: Vis-à-vis the underlying molecular pathways of EA extract on cell proliferation, EMT progression, cell invasion, and colony formation of HER2-positive breast cancer cells, we assumed that HER2 activation, as well as c-Jun N-terminal kinase (JNK), could have major roles in regulating these events [36,37,38,39]; therefore, the expression patterns of HER2 and JNK1/2 were explored.