ERBB2 and breast cancer: Subsequently, and to analyze the anti-invasion effects of EA on HER2-positive breast cancer cells, Matrigel invasion assay was performed, using SKBR3 and ZR75-1 cells, upon EA treatment with 100 and 200 μL/mL concentrations; our data revealed that EA extract significantly inhibits cell invasion ability of both cell lines by ~70% to 88%, respectively, in comparison with control cells (Figure 5, p < 0.05).