The prevention of complete suppression of the reproductive axis may be of therapeutic value in some conditions, as evidenced by the frequent need for “add back” estrogen in the treatment of uterine fibroids and endometriosis using GnRH analogues to reduce otherwise overly troublesome symptoms of estrogen deficiency and to mitigate bone mineral loss (23, 24). Here, GNRH1 is linked to uterine corpus leiomyoma.