This suppression of the apoptosis pathway induced by LY-249002 may indicate the induction of a tumor cell survival program in U87MG cells, as suggested by the parallel up-regulation of growth-associated genes encoding the insulin-like growth factor 1 receptor (IGF1R), TNF receptor superfamily member 1B (TNFRSF1B) and the Bcl-2 like 11 (Bcl-2L11) genes. This evidence concerns the gene TNFRSF1B and neoplasm.