IDH1 and central nervous system cancer: Despite central character of mutant IDH1 protein in gliomagenesis, reports in the literature showed that mutant IDH1 promotes apoptosis by sensitizing glioma cells to ER stress through upregulation of miR-183 and suppression of its target Semaphorin E3, or by negatively regulating Wnt/β-catenin signaling [46, 47].