Nevertheless, most of our data correlating PitNET-derived cytokines and angiogenic parameters were non-significant, including those for recognised angiogenic factors such as VEGF-A [11, 62], FGF-2 [12, 25] and IL-8 [63], possibly implying that cytokines released by pituitary tumour cells per se may play a limited direct effect in the tumour angiogenesis. This evidence concerns the gene CXCL8 and neoplasm.