GABRB3 and Angelman syndrome: Instead, GABRB3 gene is well known to be associated with complex neurologic disorders including Rett syndrome (RS), Angelman syndrome (AS), ASD, and various types of epileptic disorders, including the EEs (Epi et al., 2013; Hamdan et al., 2014; Le et al., 2017; Moller et al., 2017; Myers et al., 2017; Papandreou et al., 2016).