p16 protein is an antioncogene, recognized as a tumor suppressor whose action takes place by inhibiting the phosphorylation of the retinoblastoma protein (pRb) by binding to the cyclin‐dependent kinase complexes (CDK4–CDK6) which leads to arrest in phase G1 of the cell cycle (Fig 1).11 Here, CDKN2A is linked to neoplasm.