Pro-inflammatory cytokines, such as IL-17, play a crucial role in the expansion and declineof RA via boosting the synovial fibroblasts and immune cells along with boosting theexpression of nuclear factor (NF-κB) and down-regulating the cascade such as inflammatorymediators like TNF-α (Sengupta et al., 2011;Kamel et al., 2018). This evidence concerns the gene TNF and rheumatoid arthritis.