HOTAIR and neoplasm: There is an increasing research focus on long non‐coding RNAs.25 Several well‐known lncRNAs, such as HOTAIR, H19, MALAT1 and TUG1, have been identified as functioning as oncogenes in osteosarcoma, whereas MEG3, GAS5 and TUSC7 have been proposed to act as tumour suppressors.26 Additionally, microarray and tiling array methods have been applied to study expression profiles of lncRNAs in osteosarcoma.27 However, the functional roles and precise mechanisms of lncRNAs in osteosarcoma remain unclear.26