Following successful IT ERT in MPS I dogs,60 MPS II mice61, 62 and MPS VI cats,63, 64 MPS IIIA mice received recombinant human sulfamidase (rhSGSH) via direct injection in the cisterna magna, which showed a fall of cerebral and medullar HS levels and improved behaviour.65 This evidence concerns the gene SGSH and mucopolysaccharidosis.