On the other hand, in in vivo model of ischemia, administration of both progesterone and antagomir-Let-7i (Let-7i inhibitor) regenerated Pgrmc1 expression and lead in a significant elevation in mature BDNF level, which promotes neuronal differentiation, cellular survival, synaptic plasticity, and neurogenesis, despite precursor BDNF (pro-BDNF) levels did not change significantly, which is linked with neuronal apoptosis [1, 106]. This evidence concerns the gene BDNF and ischemia.