Leucine-rich repeat kinase 2 (LRRK2) is an important factor involved in the etiology of PD, LRRK2 mutations are the major reason of inherited and sporadic PD, and overexpression of miR-205 showed an association with the abnormal upregulation of LRRK2 in PD brains [53]. This evidence concerns the gene LRRK2 and Parkinson disease.