TLR4 and hepatocellular carcinoma: In contrast to Yu et al. (2018) and Dapito et al. (2012), on the basis of several highly sophisticated animal models, came to the conclusion that there is no significant contribution of intestinal microbiota and TLR4 to liver cancer induction but it is valid for the tumor promotion, mediating HCC proliferation, secretion of growth factors such as liver mitogen epiregulin and prevention of apoptosis.