After correction for multiple testing, type 2 diabetes–associated SNPs in or near HHEX, CDKAL1, IGF2B2, fasting glucose–associated SNPs in or near CDKAL1 and IGF2BP2, and a 2-hour glucose post-OGTT–associated SNP at the GIPR locus were all associated with beta-cell glucose sensitivity. The gene discussed is GIPR; the disease is type 2 diabetes mellitus.