NAT2 and colorectal neoplasm: The identified NAT2 SNV rs1799930 defines the NAT2*6 group of alleles, encoding slow acetylator variants with 10-fold reduced activity compared to the wild-type (NAT2*4) rapid acetylator enzyme.9 We envisioned that we could target a population of colorectal tumors originally heterozygous for a rapid and a slow acetylator allele, losing the rapid acetylator allele due to LOH during disease progression.