Accordingly, CD31 staining showed dramatically inhibited angiogenesis in MEQ-treated xenografts (P < 0.01) (Figure 5F), leading to increased tumor cell apoptosis and inhibited cell proliferation as measured by IHC staining of CC3 (P < 0.05) and Ki-67 (P < 0.05), respectively (Figure 5G and 5H). This evidence concerns the gene MKI67 and neoplasm.