In our study, to search for novel insight into mesGBM pathogenesis, we reviewed the transcriptomic signature genes of mesGBM and found the exclusive upregulation of TGFβ1 and TβRII in the mesenchymal subtype and downregulation of TGFβ3 in the proneural subtype in the TCGA GBM dataset. This evidence concerns the gene TGFBR2 and glioblastoma.