Wen et al.55 reported that the expression of PD-L1 induced by tumor cell-released autophagosomes (TRAPs) is completely myeloid differentiation primary response gene 88 (MyD88)-dependent, and the upregulation of PD-L1 is significantly weakened because of the lack of TLR4 instead of TLR2. The gene discussed is MYD88; the disease is neoplasm.