It has been demonstrated that zinc deficiency promotes the release of proinflammatory cytokines, such as TNF-α, IL-1β, IFN-γ, IL-2, IL-6, IL-8, S100a8, and S100a919, which may be attributable to the ability of zinc to regulate nuclear factor-κB (NF-κB), the master regulator of inflammatory responses. This evidence concerns the gene TNF and Zinc deficiency.