In vitro studies reported that ovarian cancer cells transfected with the miR-135a vector showed decreased viability when compared with controls transfected with blank vector, and the IC50 of paclitaxel was lower in ovarian cancer cells transfected with miR-135a, which may be explained by the direct regulation of protein phosphatase 2 regulatory subunit B beta expression and indirect regulation of baculoviral IAP repeat containing 3, gamma-aminobutyric acid receptor subunit α3 or sperm protein associated with the nucleus on the X chromosome B1/2 expressions by miR-135a27. The gene discussed is PPP2R5B; the disease is ovarian carcinoma.