FOXO1 and hepatocellular carcinoma: In hepatocellular carcinoma, for example, miR-135a increases the expression of oncogenes and the phosphorylation of AKT to promote the migration and invasion of HCC cells26, but it suppresses the forkhead box O1 (FOXO1) tumor suppressor, which results in a decrease in phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in gluconeogenesis26,59.