For example, androgen receptor (AR) activates the transcription of miR-135a by directly binding to androgen response elements (AREs) in the promoter region of the MIR135A2 gene in prostate cancer cell lines; the ARE sequence, CAAGTACAGCTTGTTCTCC, is located -5,605 bp upstream of pre-miR-135a243. The gene discussed is AR; the disease is prostate cancer.