A recent study has reported an association between CMTM1_v5, an alternatively spliced protein isoform of CMTM1, and apoptosis in lymphoma cells; the interaction between CMTM1_v5 and calcium-modulating cyclophilin ligand negatively regulates the Ca2+ response in the endoplasmic reticulum in lymphoma cells and thereby results in cell apoptosis51. Here, PPIB is linked to lymphoma.