KLF4 and precursor B-cell acute lymphoblastic leukemia: As we discovered that downregulating KLF4 plays an essential role in the growth of 2 established PDX models of B-ALL in vivo and that the widely used drug Aza upregulates KLF4, our data support the further evaluation of Aza as a therapeutic strategy and the idea of applying Aza to the treatment of patients with B-ALL.