Nicotinamide adenine dinucleotide phosphate oxidase (NOX), transforming growth factor-β (TGF-β), NF-κB and nuclear factor-erythroid 2 related factor 2 (Nrf2) are prominent mediators of oxidative stress [97], which play important roles in regulating AD development. The gene discussed is TGFB1; the disease is Alzheimer disease.