Indeed, 2-(3,4-dimethoxy benzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole, a bioavailable prodrug of Ro 61–8048 (the most widely used kynurenine 3-monooxygenase inhibitor with unstable metabolic stability), selectively restrained peripheral kynurenine 3-monooxygenase and ameliorated neurodegeneration in well-established mouse model of AD via modestly elevating neuroprotective metabolite without increasing neurotoxic metabolites [48]. The gene discussed is KMO; the disease is Alzheimer disease.