In addition, Guo et al. demonstrated that hyperhomocysteinemia induced Aβ accumulation and tau hyperphosphorylation was found in the retina as well, while simultaneous B vitamins supplementation efficiently reduced plasma AD-like hyperhomocysteinemia with attenuation of AD-like Aβ and tau pathologies in the retina for the first time [76]. Here, MAPT is linked to hyperhomocysteinemia.