CD8A and infection: The reduction of total TCM cellnumbers confirmed this finding (Figure 6d) and hasbeen described earlier as type I interferon depend attrition of memory T cells [52–54].In contrast to the relatively low numbers of bona fideapoptotic CD8+ T cells, EV-decoration of CD8+ T cells increasedsignificantly in all populations, TN, TCM and TE cellsupon infection by frequency (Figure 6c) and cellnumber (Figure 6D).