These proteins that are associated with intracellular compartments beyond plasma membrane (PM)/endosomes [61] may be contaminants, but could also be bona fide cargo of bdEVs [62,66]: calnexin is carried by syncytiotrophoblast EVs with immunoregulatory function in preeclampsia [63], while ApoD transported by astroglial cells can exert neuroprotective effects [65]. Here, CANX is linked to preeclampsia.