Perhaps, the most important and widely studied component is MMP-9, known as gelatinase B. MMP-9 has been shown to represent the invasiveness of NSCLC, through induction by vascular endothelial growth factor receptor-1 (VEGFR-1)/Flt-1 tyrosine kinase (10). This evidence concerns the gene MMP9 and non-small cell lung carcinoma.