STING1 and vascular disorder: STING-associated vasculopathy with onset in infancy (known as SAVI syndrome) is an early-onset systemic inflammatory phenotype characterized by severe cutaneous vasculopathy and major interstitial lung disease, caused by enhanced sensitivity or ligand-independent (constitutive) activation of a non-nucleic acid receptor component (for example, an adaptor molecule) of the IFN-induced signalling pathway, such as in the case of de novo and inherited pathogenic variants in TMEM173 gene, which encodes the protein STING (stimulator of interferon genes) [14, 15].