VEGFA and neoplasm: We have already described the potential anti-tumor activity of immunoglobulin, thanks to its immunomodulatory role due to its action in the adaptive immunity and in the maintenance of immune homeostasis (activation of FCGR; stimulation and NK cells cytotoxic activity on tumor cells; increased expression of pro-apoptotic molecules; reduction of tumor spread by Anti-VEGF Ab and reduced expression of metalloproteinases and anti-RGD Ab, etc.)[19].