In addition, we examined the hub genes KIT, CDKN1B, RUNX2, and BCL2L11, which may act in pancreatic cancer, and confirmed that the expression of KIT, CDKN1B, RUNX2, and BCL2L11 is indeed affected by miR-221-3p. Here, CDKN1B is linked to familial pancreatic carcinoma.