Consistently, the levels of non-phosphorylated β-catenin (N-β-catenin: namely total β-catenin), cyclin D1 and c-myc proteins were also reduced, whereas that of Axin2 and phosphorylated β-catenin (P-β-catenin) were augmented in miR-300-elevated HCC cells (Fig. 2j). This evidence concerns the gene AXIN2 and hepatocellular carcinoma.