Furthermore, we observed SNHG12 was down-regulated when expression of KLF5 was knocked-down in CRC cell line (Fig. 5d, e), and the high correlation between SNHG12 and KLF5 expression in cancerous and normal tissues (Fig. 5a, b), suggesting that SNHG12 is a potential target of KLF5 in CRC. This evidence concerns the gene KLF5 and colorectal carcinoma.