CD44 and cancer: Consistent with its role in the CD44 + / CD24− population, the knockdown of KMT2C significantly elevated the SFE of SKOV3 (P < 0.01), while the over expression of KMT2C significantly inhibited the SFE of TOV21G, indicating that KMT2C was directly related to the cancer stem cells (p < 0.01) (Fig. 5e, f).