These DEGs include IL-6 and IL-1β cytokines, which are key inflammatory signals in many pain conditions such as fibromyalgia, rheumatoid arthritis, irritable bowel syndrome, etc.24; Cxcl1, Cxcl2, Cxcl5, Ccl7 and Ccl8 chemokines, which are known to be involved in nerve injury and chemotherapy-induced neuropathic pain25–27. This evidence concerns the gene CXCL5 and irritable bowel syndrome.