Unlike the elevation of vCSF-cfmtDNA seen in Braak V/VI, where the subset of samples were largely AD cases, demented cases were a cross-section of the NDD cohort (38 AD, 11 DLB, 9 FTD/VD, 3 PD, 3 PSP and 1 MND), indicating that this result is somewhat independent of regional tau pathology. This evidence concerns the gene MAPT and frontotemporal dementia.