Beyond AD35, the CP is not typically subject to gross neurodegeneration in NDD but does exhibit biological and pathophysiological changes associated with ageing and age-related disease36, including reduced CSF production and turnover, increased lipid (Biondi bodies) and protein (Aβ and α-synuclein) aggregates and reduced metabolic and enzymatic activity35,36. This evidence concerns the gene SNCA and Neurodevelopmental delay.