Stratification of cases by the diagnosis of dementia revealed both a significant elevation of NSE (TTEST p = 0.038, Fig. 2d and STable 2a) and a significant reduction of 14–3-3 zeta in NDD cases with dementia when compared to NDD cases without dementia (TTEST p = 0.006, Fig. 2e and STable 2a). Here, ENO2 is linked to dementia.