Within the DE-mRNAs are factors that are clearly related to neuronal development (NID2, VIM, NTN1, SEMA3, EYA1, CDH19), brain transport and neurotransmission (SLC13A3, SLC6A20, SLC6A12, MOCOS, TRPM4, KCNJ13, CUBN, MRASAL1), brain injury (FN1, BHMT2, PATL2, GDF10, GSN, FGL2, OTOF, VCAM1, PROS1, COL4A5, EFEMP1, NPFFR2, LAMA2, ADAM12, MYOF) and neurodegenerative diseases associated with Al like AD (ND6, STOML2, MRC1, KDR, NEIL2), Parkinson Disease (PD) (ATP13A5, HIST1H1C) and Amyotrophic Lateral Sclerosis (ALS) (ANXA2) (Fig. 3b). This evidence concerns the gene PROS1 and amyotrophic lateral sclerosis.