Within the DE-mRNAs are factors that are clearly related to neuronal development (NID2, VIM, NTN1, SEMA3, EYA1, CDH19), brain transport and neurotransmission (SLC13A3, SLC6A20, SLC6A12, MOCOS, TRPM4, KCNJ13, CUBN, MRASAL1), brain injury (FN1, BHMT2, PATL2, GDF10, GSN, FGL2, OTOF, VCAM1, PROS1, COL4A5, EFEMP1, NPFFR2, LAMA2, ADAM12, MYOF) and neurodegenerative diseases associated with Al like AD (ND6, STOML2, MRC1, KDR, NEIL2), Parkinson Disease (PD) (ATP13A5, HIST1H1C) and Amyotrophic Lateral Sclerosis (ALS) (ANXA2) (Fig. 3b). The gene discussed is COL4A5; the disease is amyotrophic lateral sclerosis.