The majority—77% had had diabetes insipidus (DI) at time of presentation, 44% had hypothyroidism, 33% had growth hormone deficiency, 22% had adrenal insufficiency, 22% had gonadotropic deficiency, 22% had either delayed or precocious puberty, and one patient had elevated prolactin. The gene discussed is PRL; the disease is Adrenal insufficiency.