FANCD2 and adenocarcinoma: In line, CDDP-resistant H460, H1975 and mouse adenocarcinoma cells all displayed strongly elevated mTOR signaling, characterized by phosphorylation of mTORC1 target sites (p70S6KT389, 4E-BP1T37/46, and ULK1S757) and increased expression of FancD2 (Fig. 2a–c).