Relative to tumors from untreated mice, that are composed of both tumor cell types, tumors from the CDDP-treated cohort displayed upregulation of mTOR signaling, defects in LC3 processing and p62 degradation (Fig. 7b, left panel), consistent with the CDDP-induced enrichment of H460res cells observed by luminescence-based tumor monitoring. This evidence concerns the gene SQSTM1 and neoplasm.