Furthermore, although autophagy genes are not among the most common genes hit by somatic point mutations, combined monoallelic deletions in multiple autophagy genes, including MAP1LC3B (LC3) and BECN1, have been identified in cancer types such as ovarian and breast cancer by haploinsufficiency network analysis, suggesting that autophagy status might also be inferred from genome sequencing data55,56. This evidence concerns the gene MAP1LC3B and breast carcinoma.