AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: With respect to signalling downstream of Gdpd3-mediated lysophospholipid metabolism, we have shown that the AKT/mTORC1 pathway becomes more highly activated in Gdpd3−/− LT-CML stem cells compared with Gdpd3+/+ LT-CML stem cells (Fig. 5a, b).