We observed that, while Foxo3a was located within the nuclei of Gdpd3+/+ LT-CML stem cells as expected25, Foxo3a was predominantly detected in the cytoplasm of Gdpd3−/− LT-CML stem cells (Fig. 5c; Supplementary Fig. 8c). This evidence concerns the gene GDPD3 and chronic myelogenous leukemia, BCR-ABL1 positive.