GDPD3 and chronic myelogenous leukemia, BCR-ABL1 positive: To examine Gdpd3’s role in CML in vivo, we used genome-editing technology in mouse embryos to successfully establish a Gdpd3-deficient mouse strain (Gdpd3−/−) in which five bp between nucleotides 15 and 19 after the first methionine of the Gdpd3 gene were deleted (Supplementary Fig. 3).