BCR and chronic myelogenous leukemia, BCR-ABL1 positive: For this study, we used two CML mouse models: (1) SCL-tTA x TRE-BCR-ABL1 double transgenic CML mice, the so-called tet-inducible CML-affected mouse model27,28, designated herein as tet-CML mice; and (2) the retroviral BCR-ABL1 transduction CML model, termed the retro-CML-affected mouse model, designated herein as retro-CML mice.