Absolute numbers of LT-CML stem cells were comparable between Lgr4+/+ and Lgr4Gt/Gt tet-CML mice, whereas the frequency of these cells was modestly increased in Lgr4Gt/Gt tet-CML mice (Fig. 7c; Supplementary Fig. 13a). This evidence concerns the gene LGR4 and chronic myelogenous leukemia, BCR-ABL1 positive.