Notably, prostaglandin D2 (PGD2) and PGE2, which were increased in Gdpd3+/+ tet-CML BM cells compared to normal WT BMMNCs, appeared to be decreased in Gdpd3−/− tet-CML BM cells compared to Gdpd3+/+ tet-CML BM cells (Fig. 4a). The gene discussed is GDPD3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.