Application of real-time PCR analysis to these cells revealed that the Gdpd3 gene was more highly expressed in LT-stem cells and CD48+ LSK cells from tet-CML mice compared to the same populations from healthy littermate control mice, but that the same was not true for MPP and LK cells (Fig. 1b). The gene discussed is CD48; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.