GDPD3 and chronic myelogenous leukemia, BCR-ABL1 positive: Consistent with the accelerated initiation of CML disease observed in our tet-CML model, recipient mice transplanted with Gdpd3−/− retro-CML-LSK cells developed CML disease more rapidly than recipients transplanted with Gdpd3+/+ retro-CML-LSK cells (Fig. 2a).