We found that several non-LPA lipid mediators, including PGE2, eicosanoids, docosanoid, and Lyso-PAF, appeared to decrease in Gdpd3−/− CML-BM cells compared to Gdpd3+/+ CML-BM cells (Fig. 4), implicating Gdpd3-mediated lysophospholipid metabolism in their production. Here, GDPD3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.