GDPD3 and chronic myelogenous leukemia, BCR-ABL1 positive: Thus, our work has uncovered and linked two features of CML stemness: (1) the lysophospholipase D Gdpd3 is critical for maintaining primitive CML stem cells in an oncogene-independent manner, and (2) lysophospholipid metabolism produces vital lipid mediators and regulates multiple downstream pathways, including GPCR-mediated signalling, that are essential for CML stem cell function.