GDPD3 and chronic myelogenous leukemia, BCR-ABL1 positive: Strikingly, we found that mRNA levels of Lgr4/Gpr48, which encodes a leucine-rich repeat (LRR)-containing GPCR, were also significantly lower in Gdpd3−/− LT-CML stem cells than in Gdpd3+/+ LT-CML stem cells (Fig. 7a).