RNA-Seq followed by gene ontology (GO) term enrichment analyses indicated that several GPCR family genes, including Lpar4/Gpr23, Ltb4r1/Gpr16, Gpr82, and Gpr84, were decreased in Gdpd3−/− LT-CML stem cells compared to Gdpd3+/+ LT-CML stem cells (Fig. 7a; Supplementary Fig. 11a, b). This evidence concerns the gene GDPD3 and chronic myelogenous leukemia, BCR-ABL1 positive.