In contrast, PGE2 treatment dramatically increased Foxo3a/β-catenin interaction in the nuclei of Lgr4Gt/Gt tet-CML stem cells, exposing an interesting difference between Gdpd3−/− LT-CML stem cells and Lgr4Gt/Gt LT-CML stem cells that remains under investigation. This evidence concerns the gene FOXO3 and chronic myelogenous leukemia, BCR-ABL1 positive.