However, it is possible that lysophospholipid metabolism as shaped by Gdpd3 regulates Lgr4/Gpr48 mRNA levels in CML stem cells, which in turn might support the self-renewal capacity of these cells and thus their maintenance in vivo (Fig. 8c). The gene discussed is GDPD3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.