In DLBCL, overexpression of Bcl-2 most commonly results from the t(14,18) translocation, which is detected in ~40% of cases belonging to the GCB-DLBCL subset, or because of BCL2 gene amplification, which occurs in ~30% of ABC DLBCL tumors25. The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.