CD40LG and B-cell chronic lymphocytic leukemia: Given the observation that BDA-366 decreased Mcl-1 expression and that Mcl-1 is a key mediator of apoptosis resistance in CLL cells, we investigated viability of BDA-366-treated CLL cells following stimulation with immobilized anti-IgM, which is known to increase CLL cell survival by upregulating Mcl-133,34.